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Penbritin 500 MG / 5 ml SUSPENSION 100ML, Ampicillin

Penbritin 500 MG / 5 ml SUSPENSION 100ML, Ampicillin
Model:750138549115
Current Reviews:0
Price:$12.50

Penbritin 500 MG / 5 ml SUSPENSION 100ML, Ampicillin

INDICATIONS: Penbritin ® is indicated for the treatment of infections due to susceptible bacilli cocci and Gram-positive and Gram-negative infections cause different location and severity, acute, chronic and recurrent, which include: Group B Streptococcus, Enterococcus faecalis and faecium, Haemophilus influenzae, Listeria monocytogenes, Proteus mirabilis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus sp, Neisseria sp, Branhamella catarrhalis, Klebsiella pneumoniae.

Tract infections: respiratory, digestive, urinary, genital.

Meningitis and septicemia.

Endocarditis.

Treatment and prophylaxis in dentistry.

Respiratory:

AOM.

Croup.

Croup.

Sinusitis.

Nasofaringoconjuntivitis.

Pneumonia.

Bronchopneumonia.

Digestive:

Shigellosis.

Salmonellosis.

Gastroenteritis.

Urinary:

Pyelonephritis.

Cystitis.

Urethritis.

Genital and ginecoobstétricas:

During pregnancy.

In chorionic premature rupture of membranes.

Puerperal and neonatal infections by Listeria monocytogenes.

Eye infections:

Skin and osteoarticular:

In infection intermediately susceptible strains Penbritin ® combined with an aminoglycoside increases its effectiveness. In all cases, before treatment with Penbritin ® bacteriological cultures should be requested to identify the causative organisms and their sensitivity to antibiotics.

It is advisable to book the injectable form, for moderately severe infections and severe and / or when it can be administered orally.

Pharmacokinetics in humans:

Capsules and Tablets: Penbritin ® by being stable in acid medium are absorbed well through the gastrointestinal tract, 30-60% of the administered dose. Blood levels reached 3-6 mcg / ml in a maximum time of 1-2 hours after administration of 500 mg orally. With administration of 1 g blood levels are doubled.

Metabolism: Hepatic acylases by the metabolite 6-aminopenicillanic acid.

Distribution: Penbritin ® for its volume of distribution of 0.28 ± 0.007 l / kg was rapidly and widely distributed to body tissues and fluids, including ascites fluid, pleural, synovial, liver and biliary tract, lungs, bronchial secretions, sputum, tonsils, sinuses sinuses, middle ear, bone and muscle.

Penbritin ® reaches minimum inhibitory concentrations higher than those of most susceptible germs, producers of the most common infections; your Penbritin ® Cmax is dose dependent:

MIC90-Positive 0.12 - 4.0 mcg / ml

MIC90-Negative 0.01 - 4.0 mcg / ml

Anaerobic MIC90 0.025 - 6.2 mcg / ml

Spirochetes MIC90 0.25 - 3.2 mcg / ml

Elimination: 60 to 80% of the dose is excreted unchanged by the kidney, which explains its effectiveness in urinary tract infections. Bile excreted by less than 20% of the dose which explains their effectiveness in gastrointestinal tract infections. Less than 11% is excreted as metabolites.

In 20% binds to plasma proteins.

Efficacy of ampicillin susceptible Penbritin ® on germs has remained: its serum concentration as their cerebrospinal fluid concentrations occur only inflamed meninges.

The elimination half-life is about 4 hours.

Injectable Solution: After applying Penbritin ® 500 mg intramuscularly, peak plasma levels (10-12 mcg / ml) are reached Tmax of 30-60 minutes. Joins by 20% to plasma proteins. Reach bactericidal concentration levels in tissues and body fluids by its rapid spread to ascites fluid, synovial and pleural, liver and biliary tract, lungs, bronchial secretions, sputum, tonsils, sinuses, middle ear and bone and muscle tissue.

Penbritin ® reaches minimum inhibitory concentrations higher than those of most susceptible germs, producers of the most common infections; your Penbritin ® Cmax is dose dependent:

MIC90-Positive 0.12 - 4.0 mcg / ml

MIC90-Negative 0.01 - 4.0 mcg / ml

Anaerobic MIC90 0.025 - 6.2 mcg / ml

Spirochetes MIC90 0.25 - 3.2 mcg / ml

The effectiveness of the ampicillin (Penbritin ®) on remained susceptible germs by its concentration in the biliary tract which is 1-12 times greater than in the serum, that their cerebrospinal fluid concentrations occur only inflamed meninges; their metabolism liver is 7 to 11% hydrolysis and renally eliminated in 90% as ampicillin base. The elimination half-life is about 4 hours.

Oral suspension: It is stable in the acidic environment of the stomach. After administration of 500 mg orally Penbritin ®, 30-60% is absorbed in the gastro tract. Peak blood levels (3-6 mcg / ml) were reached in a Tmax of 1.5 to 2 hours. The plasma half-life is 1-2 hours. In 20% binds to plasma proteins.

Reach bactericidal concentration levels in tissues and body fluids by its rapid spread to ascites fluid, synovial and pleural liver and biliary tract, lungs, bronchial secretions, sputum, tonsils, sinuses, middle ear and bone and muscle tissue.

The effectiveness of the ampicillin (Penbritin ®) on remained susceptible germs by its concentration in the biliary tract which is 1-12 times greater than in the serum, that their cerebrospinal fluid concentrations occur only inflamed meninges; their metabolism liver is 7 to 11% hydrolysis and is eliminated renally ampicillin at 90% in about 4 hours basis.

CONTRAINDICATIONS: Penbritin ® is contraindicated in patients with a history of allergy to penicillins and / or cephalosporins.

PRECAUTIONS: Hypersensitivity Possibly crossed with cephalosporins. Antibiotic therapy with high doses and over time may result in fungal or bacterial superinfection. In patients with infectious mononucleosis or lymphatic leukemia can desarrrollar rash.

RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING far not established the safety of ampicillin during pregnancy, their use is the responsibility of the treating physician to a justified indication where the benefits outweigh the risks. Due to the passage of small amounts of ampicillin to the placenta and breast milk, caution should be exercised and monitoring the infant during antibiotic therapy of the mother.

ADVERSE REACTIONS: As with all penicillins, allergic reactions can occur: fever, urticaria, pruritus, nausea, vomiting and diarrhea. Eosinophilia Rarely, angioedema and anaphylactic shock. More likely in individuals hypersensitive to penicillin or a history of allergy, asthma, hay fever or urticaria.

Precautions: Antibiotic therapy with high doses and over time may result in fungal or bacterial superinfection. In patients with infectious mononucleosis or lymphatic leukemia may develop rash.

DRUG INTERACTIONS AND OTHER GENDER: Administration with food decreases absorption. Concomitant use of allopurinol increases the risk of skin rash. Probenecid facilitates increased blood levels and reduces the time of excretion of ampicillin. Ampicillin has been associated with a temporary reduction in plasma levels of estrogen during treatment anovulatory.

By adding an aminoglycoside Penbritin ®, increases its bactericidal spectrum. However, simultaneous administration should be avoided in the same solution for infusion.

CHANGES IN RESULTS OF LABORATORY TESTS false positive reactions may occur in nylidrin tests, enzymatic reactions of glucose in urine and urobilinogen tests. In rare cases can occur reversible increase liver values ​​of SGPT, SGOT and / or alkaline phosphatase.

In isolated cases have been reported profile changes bloody, prolonged treatment with high doses.

These changes resolve after stopping the drug. In rare cases high doses by IV administration crystalluria can give.

PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility: To date there is no evidence that ampicillin has effects on carcinogenicity, mutagenicity, teratogenicity and fertility.

DOSAGE AND ADMINISTRATION:

Capsules: Oral.

In children under 14 years of age: The recommended dose weight is 50 to 100 mg / kg / day divided into 4 doses (one every six hours) should be given for a period not less than 7 days.

Adults and children over 14 years: 500 mg to 1 g every 6 hours administered VO or parenterally. In patients with severe impairment of renal function (creatinine clearance <30 ml / min) should be given the usual doses with a frequency of every 12 hours.

Solution for injection: Parenteral.

Children:

<20 kg 250-500 mg C / 6 hours I.M. or I.V.

> 25-50 kg 20 mg / kg / day divided in equal doses every 6 to 8 hours.

Bacterial meningitis and septicemia in children:

150 to 200 mg / kg / day divided every 3 to 4 hours.

Starting I.V. drip administration and continued I.M.

Adults: 500 mg-2 g C / 8 hours.

Infections caused by N. gonorrhoeae (urethral, ​​rectal, pharyngeal and cervical): 3.5 g of ampicillin plus 1 g probenecid as a single dose.

Bacterial meningitis and sepsis in adults from 150 to 200 mg / kg / day divided every 3 to 4 hours. Starting I.V. drip administration and continued I.M.

In patients with severe impairment of renal function (creatinine clearance <30 ml / min) should be of the usual doses administered with a frequency of every 12 hours.

In children under 14 years of age: The recommended dose weight is 50 to 100 mg / kg / day divided into 4 doses (one every six hours) should be given for a period not less than 7 days.

Adults and children over 14 years: 500 mg to 1 g every 6 hours administered VO or parenterally.

In patients with severe impairment of renal function (creatinine clearance <30 ml / min) should be given the usual doses with a frequency of every 12 hours.

Suspension: Oral.

Each 5 ml of suspension equivalent to 250 or 500 mg of ampicillin.

In children under 14 years of age: The recommended dose weight is 50 to 100 mg / kg / day divided into 4 doses (one every six hours) should be given for a period not less than 7 days.

Adults and children over 14 years: 500 mg to 1 g every 6 hours administered VO

In severe infections the dose recommended weight is 200 to 400 mg / kg / day divided into 4 doses.

In patients with severe impairment of renal function (creatinine clearance <30 ml / min) should be of the usual doses administered with a frequency of every 12 hours.

Tablets: Oral.

Weight dose in adults and children over 14 years: 50 mg to 1 g every 6 hours, given VO

MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION: Like other penicillins, extremely high serum concentrations can cause cramps (neurotoxic reactions), requiring discontinuation of treatment. In case of overdose, the patient can hemodializar.

PRESENTATIONS:

Penbritin ® Capsules: Box with 20 capsules of 500 mg.

Penbritin ® Solution for injection: Box of 3 vials of 500 mg.

Box of 3 vials of 1 g.

Penbritin ® Suspension: Box c / jar susp. 250 mg /
100 ml with dosing.

Box c / jar susp. 500 mg/100 ml with dosing.

Penbritin ® Tablets: Box of 12 tablets of 1 g.

RECOMMENDED STORAGE: Store at room temperature not exceeding 30 ° C and dry.

For suspension: Keep the bottle tightly closed. Of mixing, the product is stored 7 days at room temperature not exceeding 30 ° C.
Drug Name: Penbritin
Comparable patent medicine: PENTREXYL
Active substance: Ampicillin
Presentation: Suspension
Concentration: 500mg/5ml
Prolonged release tablets: No
Lab: LAB HORMONA
Bottle with powder for 100ml and dispenser
Made in Mexico

   
   
   
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